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Algorithmic Thinking in Bioinformatics Quiz 2: 16 March 2025 (January 2025 term)

Question 1

+2 marksOne correct option

Consider a univariate Gaussian Mixture Model (GMM) with 3 components. Suppose for component 2, you are given the following data points and corresponding responsibilities. Which of the following options correctly represents the updated mean μ2\mu_2?

xix_iri,2r_{i,2}
30.1
70.7
100.6
50.4
80.8
  1. A
  2. B
  3. C
  4. D

Question 2

+3 marksOne correct option
  1. A
  2. B
  3. C
  4. D

Question 3

+5 marksOne correct option

Given below are three algorithms for the motif finding problem. Identify which figure belongs to which algorithm.

text
████████
randomly select k-mers Motifs = (Motif_1, ..., Motif_t) in each string from Dna
BestMotifs ← Motifs
for j ← 1 to N
i ← RANDOM(t)
Profile ← profile matrix formed from all strings in Motifs except for Motif_i
Motif_i ← Profile-randomly generated k-mer in the i-th sequence
if SCORE(Motifs) < SCORE(BestMotifs)
BestMotifs ← Motifs
return BestMotifs

(a) Figure I

text
████████
BestMotifs ← motif matrix formed by first k-mers in each string from Dna
for each k-mer Motif in the first string from Dna
Motif_1 ← Motif
for i = 2 to t
form Profile from motifs Motif_1, ..., Motif_{i-1}
Motif_i ← Profile-most probable k-mer in the i-th string in Dna
Motifs ← (Motif_1, ..., Motif_t)
if SCORE(Motifs) < SCORE(BestMotifs)
BestMotifs ← Motifs
return BestMotifs

(b) Figure II

text
████████
randomly select k-mers Motifs = (Motif_1, ..., Motif_t) in each string from Dna
BestMotifs ← Motifs
while forever
Profile ← PROFILE(Motifs)
Motifs ← MOTIFS(Profile, Dna)
if SCORE(Motifs) < SCORE(BestMotifs)
BestMotifs ← Motifs
else
return BestMotifs

(c) Figure III

  1. A

    Figure I: Gibbs Sampling; Figure II: Randomized Motif Search; Figure III: Greedy Motif Search

  2. B

    Figure I: Gibbs Sampling; Figure II: Greedy Motif Search; Figure III: Randomized Motif Search

  3. C

    Figure I: Greedy Motif Search; Figure II: Randomized Motif Search; Figure III: Gibbs Sampling

  4. D

    Figure I: Randomized Motif Search; Figure II: Gibbs Sampling; Figure III: Greedy Motif Search

Also asked in Quiz 2 3 Aug 2025

14 more questions in this paper

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More on the Algorithmic Thinking in Bioinformatics Quiz 2 16 Mar 2025 paper

The IIT Madras BS Algorithmic Thinking in Bioinformatics (Algorithmic Thinking in Bioinformatics) Quiz 2 paper sat on 16 Mar 2025, in the January 2025 term: 17 questions for 50 marks in 120 minutes. The first 3 questions are below. Sign in with Google — it is free — to see the whole paper with its answers and explanations, in learning mode or as a timed mock test.

FeatureAlgorithmic Thinking in Bioinformatics Quiz 2 16 Mar 2025 at a glance
TermJanuary 2025 term
SubjectAlgorithmic Thinking in Bioinformatics
Course codeBSBT4001
Questions17
Marks50
Duration120 min
MCQ8
Numerical5
MSQ4
Official paperIIT M DEGREE AN EXAM QDB2 16 Mar 2025
Negative markingNo negative marking.
Updated

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