You enter an alien world as a renowned computational biologist. The table below is presented to you as part of a preliminary study done by a group of scientists to study the local fauna around the base camp. They have analyzed the DNA and figured out that there are only two bases “+” and “0”. The table below represents the DNA sequence in 6 positions for the different species found. The DNA sequence ("+" and "0") | species | 1 | 2 | 3 | 4 | 5 | 6 | |---|---|---|---|---|---|---| | A | 0 | + | + | 0 | 0 | + | | B | + | 0 | 0 | 0 | 0 | + | | C | 0 | + | + | 0 | + | + | | D | 0 | 0 | 0 | 0 | 0 | 0 | | E | 0 | + | + | 0 | + | + | Based on the above data, answer the given subquestions. The scientists have tried to construct the distance matrix as follows: | | A | B | C | D | E | |---|---|---|---|---|---| | A | 0 | 3 | 1 | 4 | 1 | | B | | 0 | 4 | 2 | 3 | | C | | | 0 | 4 | 1 | | D | | | | 0 | 4 | | E | | | | | 0 | Your task is to verify if the distance matrix is correct, and if there are wrong values in the matrix, then substitute with the correct values. Which among the following represent the corrections you have to make? Here d[x, y] represents the hamming distance between the x and y species.

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Algorithmic Thinking in Bioinformatics · Quiz 2 · 4 Aug 2024 · May 2024 term

Question 4: You enter an alien world as a renowned computational biol…

Question 4

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You enter an alien world as a renowned computational biologist. The table below is presented to you as part of a preliminary study done by a group of scientists to study the local fauna around the base camp. They have analyzed the DNA and figured out that there are only two bases “+” and “0”. The table below represents the DNA sequence in 6 positions for the different species found.

The DNA sequence ("+" and "0")

species	1	2	3	5	6
A	0	+	+	0	+
B	+	0	0	0	+
C	0	+	+	+	+
D	0	0	0	0	0
E	0	+	+	+	+

Based on the above data, answer the given subquestions.

The scientists have tried to construct the distance matrix as follows:

	A	B	C	D	E
A	0	3	1	4	1
B		0	4	2	3
C			0	4	1
D				0	4
E					0

Your task is to verify if the distance matrix is correct, and if there are wrong values in the matrix, then substitute with the correct values. Which among the following represent the corrections you have to make? Here $d[x, y]$ represents the hamming distance between the $x$ and $y$ species.

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Question 4 of 15 in the IIT Madras BS Algorithmic Thinking in Bioinformatics (Algorithmic Thinking in Bioinformatics) Quiz 2 paper sat on 4 Aug 2024, in the May 2024 term (IIT M DEGREE AN EXAM QDB2 4 Aug 2024). It carries 4 marks.

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