Question 8
A potential cancer therapy drug "Y" was found to bind to certain cancer proteins in an experimental setup. Its binding efficiency (binding) was found to be based on its length (length), presence of -sheets (structure; -sheet is present, -helix), and presence of hydrophobic side chains (HSC; side chains are hydrophobic, 0 otherwise). Using protein data from TCGA (a public database), logistic regression was performed to understand the drug behavior. The results are summarized below in a table. Compute the log odds of binding of drug "Y" for Protein C with 20 amino acids
| Coefficient | Standard error | Z | p-value | |
|---|---|---|---|---|
| length | 0.9 | 0.20 | 3.16 | 0.002 |
| structure | 0.3 | 0.77 | 2.73 | 0.006 |
| HSC | 2.5 | 0.26 | 1.99 | 0.047 |
| constant | -25 | 3.28 | -2.48 | 0.013 |
with -helix structure and hydrophobic side chains and use the results to predict if this protein will bind or will not bind to the drug?
Yes, predicted to bind
No, not predicted to bind