Question 16: Suppose the score is calculated as follows: \mathit{scor…

Consider the following two global alignments for the two input DNA sequences: $v = GTTACTAG$ and $w = GGACTTACG$ and answer the given subquestions with respect to the same.

(a) Alignment 1

(b) Alignment 2

Also consider the following score matrix (S).

Table 2: Score Matrix S

Suppose the score is calculated as follows:

$\mathit{score} = \#\mathit{matches} - 2 \times \#\mathit{mismatches} + \mathit{total\ gap\ penalty}$

For every gap of length $k$, the gap penalty is calculated as $\sigma - (k-1)$, where the gap opening penalty $\sigma$ is computed from the score matrix $S$ given in Table 2. The total gap penalty is the sum of the gap penalties for every gap.

What is the difference in the alignment score?

Enter the value as a single integer.