Consider the following two global alignments for the two input DNA sequences: v = GTTACTAG and w = GGACTTACG and answer the given subquestions with respect to the same. | - | G | - | - | T | T | A | C | T | A | G | |---|---|---|---|---|---|---|---|---|---|---| | G | G | A | C | T | T | A | C | - | - | G | (a) Alignment 1 | G | - | - | - | T | T | A | C | T | A | G | |---|---|---|---|---|---|---|---|---|---|---| | G | G | A | C | T | T | A | C | - | - | G | (b) Alignment 2 Also consider the following score matrix (S). | 1st String \ 2nd String | A | C | G | T | - | |---|---|---|---|---|---| | A | 1 | -3 | -5 | -1 | -3 | | C | -4 | 1 | -3 | -2 | -3 | | G | -9 | -7 | 1 | -1 | -3 | | T | -3 | -5 | -8 | 1 | -4 | | - | -4 | -2 | -2 | -1 | | Table 2: Score Matrix S Suppose we compute the score using the score matrix (S). What is the difference in the alignment score for the two global alignments? Enter the value as a single integer.

Algorithmic Thinking in Bioinformatics · Quiz 1 · 23 Feb 2025 · January 2025 term

Question 15: Suppose we compute the score using the score matrix (S).…

Question 15

+2 marksNumerical answer

Consider the following two global alignments for the two input DNA sequences: $v = GTTACTAG$ and $w = GGACTTACG$ and answer the given subquestions with respect to the same.

-	G	-	-	T	T	A	C	T	A	G
G	G	A	C	T	T	A	C	-	-	G

(a) Alignment 1

G	-	-	-	T	T	A	C	T	A	G
G	G	A	C	T	T	A	C	-	-	G

(b) Alignment 2

Also consider the following score matrix (S).

1st String \ 2nd String	A	C	G	T	-
A	1	-3	-5	-1	-3
C	-4	1	-3	-2	-3
G	-9	-7	1	-1	-3
T	-3	-5	-8	1	-4
-	-4	-2	-2	-1

Table 2: Score Matrix S

Suppose we compute the score using the score matrix (S). What is the difference in the alignment score for the two global alignments? Enter the value as a single integer.

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Question 15 of 16 in the IIT Madras BS Algorithmic Thinking in Bioinformatics (Algorithmic Thinking in Bioinformatics) Quiz 1 paper sat on 23 Feb 2025, in the January 2025 term (IIT M DEGREE AN EXAM QDB2 23 Feb 2025). It carries 2 marks.

Question 15: Suppose we compute the score using the score matrix (S).…

Question 15

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