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Algorithmic Thinking in Bioinformatics · Quiz 1 · 13 Jul 2025 · May 2025 term

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Question 13

+2 marksOne correct option

Given below in Figure 2 is the BLOSUM50 scoring matrix for amino acids. Use the same as the scoring matrix and answer the given subquestions.

ACDEFGHIKLMNPQRSTVWY
A5-1-2-1-30-2-1-1-2-1-1-1-1-2100-3-2
C-113-4-3-2-3-3-2-3-2-2-2-4-3-4-1-1-1-5-3
D-2-482-5-1-1-4-1-4-42-10-20-1-4-5-3
E-1-326-3-30-41-3-20-120-1-1-3-3-2
F-3-2-5-38-4-10-410-4-4-4-3-3-2-114
G0-3-1-3-48-2-4-2-4-30-2-2-30-2-4-3-3
H-2-3-10-1-210-40-3-11-210-1-2-4-32
I-1-2-4-40-4-45-322-3-3-3-4-3-14-3-1
K-1-3-11-4-20-36-3-20-1230-1-3-3-2
L-2-2-4-31-4-32-353-4-4-2-3-3-11-2-1
M-1-2-4-20-3-12-237-2-30-2-2-11-10
N-1-220-401-30-4-27-20-110-3-4-2
P-1-4-1-1-4-2-2-3-1-4-3-210-1-3-1-1-3-4-3
Q-1-302-4-21-32-200-1710-1-3-1-1
R-2-4-20-3-30-43-3-2-1-317-1-1-3-3-1
S1-10-1-30-1-30-3-21-10-152-2-4-2
T0-1-1-1-2-2-2-1-1-1-10-1-1-1250-3-2
V0-1-4-3-1-4-44-311-3-3-3-3-205-3-1
W-3-5-5-31-3-3-3-3-2-1-4-4-1-3-4-3-3152
Y-2-3-3-24-32-1-2-10-2-3-1-1-2-2-128

Figure 2: BLOSUM50 scoring matrix for amino acids

Global alignment among which of the following pairs of the peptides results in the maximum alignment score? Here Xⁿ represents the string with the amino acid X repeated n times.

  1. A

    W⁵⁰ and W⁵⁰

  2. B

    RW²⁵RW²⁵ and RW²⁵RW²⁵

  3. C

    RW⁴⁸R and RW⁴⁸R

  4. D

    R⁵⁰ and R⁵⁰

Show answer

Correct answer

  • B

    RW²⁵RW²⁵ and RW²⁵RW²⁵

See the whole paperTake it as a mock test

Question 13 of 15 in the IIT Madras BS Algorithmic Thinking in Bioinformatics (Algorithmic Thinking in Bioinformatics) Quiz 1 paper sat on 13 Jul 2025, in the May 2025 term (IIT M DEGREE AN EXAM QDB2 13 July 2025). It carries 2 marks.

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